The role of FXR in disorders of bile acid homeostasis.
نویسندگان
چکیده
As ligands for the nuclear receptor FXR, bile acids regulate their own synthesis, transport, and conjugation, thus protecting against bile acid toxicity. Recently, the role of genetic variants in FXR itself, FXR target genes, and regulators of FXR in the pathophysiology of the liver and intestine has become increasingly evident.
منابع مشابه
Targeted Disruption of the Nuclear Receptor FXR/BAR Impairs Bile Acid and Lipid Homeostasis
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عنوان ژورنال:
- Physiology
دوره 23 شماره
صفحات -
تاریخ انتشار 2008